Cetylpyridinium chloride


Generic Medicine Info
Indications and Dosage
Mouth/Throat
Sore throat
Adult: As 0.025% liquid: Gargle with 15 mL of undiluted liquid bid or tid. Do not swallow.
Child: >6 years Same as adult dose.

Mouth/Throat
Antiseptic, Mouth infections, Oral hygiene
Adult: As mouthwash: Rinse mouth with 15 mL or 20 mL for 30 seconds bid or tid. Do not swallow.
Child: ≥6 years Same as adult dose.

Topical/Cutaneous
Minor, superficial skin wounds, Superficial burns
Adult: As 0.025% liquid: Apply undiluted liquid onto the affected area.
Child: Same as adult dose.
Incompatibility
Incompatible with anionic surfactants (e.g. soaps).
Special Precautions
Children.
Adverse Reactions
Gastrointestinal disorders: Dental or tongue discolouration, mouth irritation.
Immune system disorders: Hypersensitivity reactions.
Patient Counseling Information
Do not use over extensive areas of the body or use for prolonged periods. Avoid contact with eyes.
Overdosage
Symptoms: Accidental ingestion of large quantities may result in pain, nausea, vomiting, diarrhoea, slurred speech, euphoria, muscle incoordination, impaired consciousness, coma, and hypoglycaemia in children. Management: Supportive treatment. Perform gastric aspiration and lavage. Administer oral or IV glucose for hypoglycaemia in children.
Action
Description:
Mechanism of Action: Cetylpyridinium chloride, a quaternary cationic antiseptic with activity against both gram-positive and gram-negative organisms.
Chemical Structure

Chemical Structure Image
Cetylpyridinium chloride_01

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 31239, Cetylpyridinium chloride. https://pubchem.ncbi.nlm.nih.gov/compound/Cetylpyridinium-chloride. Accessed Aug. 25, 2020.

Storage
Store below 30°C. Protect from light.
MIMS Class
Preparations for Oral Ulceration & Inflammation / Skin Antiseptics & Disinfectants
References
Advanced Guard Rinse (H-E-B). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/08/2020.

Alcohol Free Antiseptic Mouthwash (Rite Aid). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/08/2020.

Anon. Cetylpyridinium. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/08/2020.

Buckingham R (ed). Cetylpyridinium Chloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/08/2020.

First Aid Antiseptic Liquid or Antiseptic Liquid (The Boots Company PLC). MHRA. https://products.mhra.gov.uk/. Accessed 06/08/2020.

Therabreath Healthy Gums Oral Rinse (Dr. Harold Katz, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/08/2020.

Disclaimer: This information is independently developed by MIMS based on Cetylpyridinium chloride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
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